Evaluation of Asthma Biomarkers and Pulmonary Function Tests in Children with Asthma

Tekcan, Ahmet; G�ven, �irin; Ku��u, Demet; Yazar, Ahmet Sami; Pala, Emin

Evaluation of Asthma Biomarkers and Pulmonary Function Tests in Children with Asthma [Haydarpasa Numune Med J]

Haydarpasa Numune Med J. 2014; 54(1): 1-7

Evaluation of Asthma Biomarkers and Pulmonary Function Tests in Children with Asthma

Ahmet Tekcan¹, �irin G�ven², Demet Ku��u², Ahmet Sami Yazar², Emin Pala²
¹�mraniye E�itim ve Ara�t�rma Hastanesi, Aile Hekimi Klini�i
²�mraniye E�itim ve Ara�t�rma Hastanesi, �ocuk Sa�l�� ve Hastal�klar� Klini�i

INTRODUCTION: Asthma is a chronic inflammatory disease of respiratory tract. many different invasive and noninvasive tests are performed to diagnose asthma. Yet no definite criteria for diagnosing asthma are determined.
METHODS: In our study we aimed to show the relation between blood parameters and pulmonary function tests (PFT) with the asthma severity in patients with a diagnosis of asthma, and post-treatment changes in these parameters.
RESULTS: Children aged 0-14 years with asthma seen in our outpatient policlinic were prospectively evaluated. Complete blood count, ECP, specific IgE,Total IgE levels of the patients are recorded at the beginning of the study. Children > 6 years performed spirometry. All patients filled a study registration form that includes major and minor risk factors. We classified the severity of the disease according to GINA (Global Initiative for Asthma) and we followed the treatment protocol. The severity of the disease did not show any significant
correlations with the gender, atopic history and family history. A statistically significant difference was found between the ECP, Total IgE levels and severity of asthma. We observed a decrease in the asthma severity during 2nd visit.
DISCUSSION AND CONCLUSION: Our results showed that serum ECP levels are significantly correlated with the severity of asthma and may be useful in the assessment of asthma control. Hence the PFT is quite difficult to perform in children, noninvasive parameters are becoming more important for the follow up of the treatment.

Keywords: Asthma, eosinophil cationic protein, childhood, pulmonary function test

Ast�ml� �ocuklarda Ast�m Biyomarkerlerinin ve Solunum Fonksiyon Testlerinin De�erlendirilmesi

G�R�� ve AMA�: Ast�m hava yollar�n�n kronik inflamatuar bir hastal��d�r. Ast�m tan�s�nda klinik bulgularla birlikte bir�ok invazif ve noninvazif testler �nerilmektedir. Ne yaz�k ast�m tan�s�nda kesin tan� kriterleri belirlenmemi�tir.
Y�NTEM ve GERE�LER: �al��mam�zda ast�m tan�s� alan hastalar�n ast�m derecesi ile kan parametreleri ve solunum fonksiyon testlerinin aras�ndaki ili�kiyi ve tedavi sonras� bu parametrelerde de�i�iklikleri g�stermeyi ama�lad�k.
BULGULAR: Poliklini�imize ba�vuran 0-14 ya� aras�ndaki ast�ml� �ocuklar prospektif olarak de�erlendirildi. Hastalar�n geli� tam kan say�m�, ECP, spesifik IgE, Total IgE tetkikleri kaydedildi. Alt� ya��ndan b�y�k �ocuklara spirometri ile solunum fonksiyon testleri yap�ld�. Takibe al�nan her hastaya muayene �ncesinde major ve min�r risk fakt�rlerini i�eren kay�t formu dolduruldu. Global Initiative for Asthma (GINA) tedavi k�lavuzu kriterlerine g�re hastalar�n ast�m �iddeti s�n�fland�r�ld� ve tedavi protokol� uyguland�. Hastalar�n ast�m �iddeti ile cinsiyetleri, atopi �yk�s� ve ailelerindeki ast�m �yk�s� aras�nda istatistiksel a��dan anlaml� bir farkl�l�k bulunmad�. Ast�m �iddeti ile ECP
de�erleri ve Total IGE de�erleri aras�nda istatistiksel a��dan anlaml� bir farkl�l�k saptand�. �kinci geli�te hastalar�n ast�m �iddetlerinde azalma g�r�ld�.
TARTI�MA ve SONU�: Bulgular�m�z serum ECP de�erlerinin ast�m�n �iddeti ile anlaml� bir korelasyon ve ast�m kontrol�n�n de�erlendirilmesinde yararl� olabilece�ini g�stermektedir. �ocuklarda SFT� nin uygulamas�nda uyum sa�lamak olduk�a zor oldu�u i�in takiplerde di�er noninvazif
parametrelerin de�erlendirilmesi �nem kazanmaktad�r.

Anahtar Kelimeler: Ast�m, eozinofil katyonik protein, �ocukluk �a��, solunum fonksiyon testi

Ahmet Tekcan, �irin G�ven, Demet Ku��u, Ahmet Sami Yazar, Emin Pala. Evaluation of Asthma Biomarkers and Pulmonary Function Tests in Children with Asthma. Haydarpasa Numune Med J. 2014; 54(1): 1-7

Corresponding Author: Ahmet Tekcan, T�rkiye
Manuscript Language: Turkish

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