Serum Eosinophil Cationic Protein Levels In Asthmatic Children

Cengiz, Mehmet; Bo�a, Aysun; Hati&775;po�lu, Sad�k Sami

Serum Eosinophil Cationic Protein Levels In Asthmatic Children [Haydarpasa Numune Med J]

Haydarpasa Numune Med J. 2016; 56(2): 87-92

Serum Eosinophil Cationic Protein Levels In Asthmatic Children

Mehmet Cengiz¹, Aysun Bo�a¹, Sad�k Sami Hati&775;po�lu²
¹Fatih Sultan Mehmet E�itim ve Ara�t�rma Hastanesi, �ocuk Sa�l�� ve Hastal�klar� Klini�i, Uzman Doktor
²Bak�rk�y Dr.Sadi Konuk E�itim ve Ara�t�rma Hastanesi, �ocuk Sa�l�� ve Hastal�klar� Klini�i, Do�ent Doktor, Klinik �efi

INTRODUCTION: Bronchial asthma is an airway disease that commonly related with allergy in children.
METHODS: Because of the routine tests tho- se used in the diagnosis of bronchial asthma could be inadequate at times, evaluation of eosinophils and eosinophil products gained importance nowadays. Eosinophil cationic protein (ECP) is a cytotoxic product of eosinophil granulocytes which has ribonuclease activity. In this study, we aimed to investigate the importance of serum ECP levels in diagnosis and follow-up of asthmatic children. Fortynine asthmatic children and 40 healthy children are included to study. Average of serum ECP levels in asthmatic children and control group was 21,45�18,7 mcg / L and 8,4 � 7,5 mcg / L, respectively. There was a significant difference in serum ECP levels when compared astmatic children with control group (p < 0,05). Sex distribution was equal in between two groups. Children in control group has a lower age than patient group (p < 0,05).
RESULTS: There was a elevation in serum ECP levels with severity of asthma. However this elevation was not statistically significant (p > 0,05). Serum ECP levels was increasing with older age and longer therapy duration in asthmatic children(p < 0,05).
DISCUSSION AND CONCLUSION: There was no effect of therapy duration on serum ECP levels when patient�s age was fixed (p > 0,05). In conclusion we think that serum ECP level can have an important role in diagnosis of asthma and follow up in therapy in children.

Keywords: Asthma, eosinophil cationic protein (ECP).

Ast�ml� �ocuklarda Serum Eozinofilik Katyonik Protein D�zeyleri

G�R�� ve AMA�: Ast�ml� �ocuklarda serum ECP d�zeylerinin, hastal��n tan� ve tedavi izlemindeki �nemini belirlemek amac�yla yapt��m�z �al��maya 49 ast�m l� ve 40 sa�l�kl� �ocuk al�nd�.
Y�NTEM ve GERE�LER: Ast�ml� �ocuklar�n serum ECP d�zeyi ortalamas� 21,45�18,7 mcg/L, kontrol grubundaki �ocuklar�n ise 8,4 � 7,5 mcg/L olarak tespit edildi. �al��ma grubundaki �ocuklar�n serum ECP de�erleri kontrol grubunun de�erleri ile kar��la�t�r�ld��nda aralar�nda anlaml� bir fark bulundu (p < 0,05). Her iki grup aras�nda cinsiyet da��l�m� e�itti (p > 0,05). Kontrol grubundaki �ocuklar�n ya�lar� hasta �ocuklar�n ya�lar�ndan daha k��k olarak bulundu (p < 0,05). �al��ma grubunda cinsiyet ile serum serumeozinofilikkatyonik protein de�erleri aras�nda istatiksel anlamda bir ili�ki g�sterilemedi (p > 0,05).
BULGULAR: Yine �al��ma grubunda ast�m �iddeti artt�k�a serum ECP d�zeylerinin artt�� g�r�ld� yaln�z bu art�� istatistiksel anlaml�l�kta de�ildi. (p > 0,05). Ast�ml� �ocuklar�n ya�lar� artt�k�a serum eozinofilik katyonik protein de�erlerinin artt�� tespit edildi (p < 0,05) ve tedavi s�resi att�k�a serum eozinofilikkatyonik protein de�erlerinin artt�� g�r�ld� (p < 0,05).
TARTI�MA ve SONU�: Ancak istatiksel analiz s�ras�nda hastalar�n ya�lar� sabit kabul edildi�inde tedavi s�resinin serum eozinofilikkatyonik protein de�erleri �zerinde etkili olmad�� tespit edildi (p > 0,05). Sonu� olarak �ocuklarda ast�m tan� ve tedavisinde g�nbeg�n de�i�en yakla��mlarda, uygulanmas� k�sa s�ren, kolay ve ucuz olan ECP d�zeyinin daha �nemli bir yer alabilece�i d��n�ld�.

Anahtar Kelimeler: Ast�m, Eozinofilikkatyonik protein.

Corresponding Author: Mehmet Cengiz, T�rkiye
Manuscript Language: Turkish

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