Haydarpasa Numune Med J. 2019; 59(2): 186-187 | DOI: 10.14744/hnhj.2018.82787

Acute Renal Injury with a Single Oral Dose of Valacyclovir: A Case Report

Miraç Ayþen Ünsal
Department of Neurology, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

We report an unusual case of valacylovir-induced nephrotoxicity. The study presents the case of a 38-year-old female patient who developed acute renal injury following treatment with a single oral dose of valacyclovir (2000 mg). Although nephrotoxicity due to rapid intravenous infusion of valacyclovir at high doses is not a rare side effect, oral single doses associated acute renal injury is an uncommon complication. Valacylovir is a commonly used antiviral agent; therefore, physicians should be aware of this rare but potentially serious adverse drug reaction.

Keywords: Acute renal injury, drug-induced nephrotoxicity; valacyclovir.

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Olgu sunumu: Tek bir oral doz valasiklovir kullanýmý ile iliþkili akut böbrek hasarý

Miraç Ayþen Ünsal
Sultan Abdülhamid Han Eðitim ve Araþtýrma Hastanesi

Nadir görülen valacylovir kaynaklý bir nefrotoksisite vakasý bildiriyoruz. Tek bir oral doz (2000 mg) valasiklovir ile tedaviyi takiben akut böbrek hasarý geliþen 38 yaþýnda kadýn hastayý sunmaktayýz. Yüksek dozlarda hýzlý intravenöz valacyclovir infüzyonuna baðlý nefrotoksisite az görülen bir yan etki deðildir. Ancak oral tek dozla iliþkili akut böbrek yetmezliði nadir görülen bir komplikasyondur. Yaygýn olarak kullanýlan bir antiviral ajan olmasý nedeniyle, bu nadir fakat potansiyel olarak ciddi yan etkinin farkýnda olunmalýdýr.

Anahtar Kelimeler: ilaca baðlý nefrotoksisite, akut böbrek hasarý, valasiklovir,

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