The Role of Genetic Factors in Specific Language Impairment

INTRODUCTION: The objective of this investigation was to determine the impact of genetic factors on SLI and to assess the role of oxidative stress and inflammation in SLI.
METHODS: A sample of 40 children, aged five, diagnosed with SLI by a licensed speech and language therapist, were selected for the study. The levels of oxidative stress (TAS, TOS, TT, and NT) and inflammation (TNF-α, IL-1β, and IL-6) were measured using photometric methods and commercially available kits. DNA damage analysis was performed using the Comet Assay technique.
RESULTS: The results showed that the levels of oxidative stress, inflammation, and DNA damage were significantly higher in the group that did not receive SLT, as compared to the control group. The levels of oxidative stress, inflammation, and DNA damage decreased significantly in the group receiving SLT compared to the group not receiving SLT.
DISCUSSION AND CONCLUSION: This study sheds light on the role of DNA damage in the presence of SLI in children and highlights the significance of oxidative stress and inflammation in Specific Language Impairment. Furthermore, it demonstrates that the levels of DNA damage, oxidative stress, and inflammation change positively with speech and language therapy support in children with Specific Language Impairments.