Vitamin D and asthma: association with pulmonary function and eosinophilic inflammation

Eryilmaz, M�zeyyen; Keskinel, Ilkay

Vitamin D and asthma: association with pulmonary function and eosinophilic inflammation [Haydarpasa Numune Med J]

Haydarpasa Numune Med J. Ahead of Print: HNHJ-28482

Vitamin D and asthma: association with pulmonary function and eosinophilic inflammation

M�zeyyen Eryilmaz¹, Ilkay Keskinel²
¹Department of Internal Medicine, Istanbul University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey
²Department of Chest Diseases, Okan University, Faculty of Medicine, Istanbul, Turkey

INTRODUCTION: Asthma is a chronic inflammatory airway disease marked by variable airflow obstruction and bronchial hyperresponsiveness. Vitamin D, known for its immunomodulatory properties, has been suggested to influence asthma pathophysiology, potentially affecting pulmonary function and eosinophilic inflammation. To investigate the differences in vitamin D levels between asthmatic patients and healthy individuals, and to analyze the correlation of vitamin D with pulmonary function, arterial oxygen saturation, and eosinophilic inflammation markers.
METHODS: This retrospective observational study reviewed medical records from 147 asthmatic patients and 30 healthy controls at a research hospital from January 2022 to January 2023. Pulmonary function tests, arterial oxygen saturation, and eosinophilic markers (eosinophil count, eosinophil percentage, total IgE, and eosinophil cationic protein levels) were analyzed.
RESULTS: No significant difference in vitamin D levels was observed between asthmatic patients and healthy controls (p = 0.543). A weak positive correlation was found between vitamin D levels and peak expiratory flow (PEF)% (r = 0.185, p = 0.025). No significant correlations were observed between vitamin D levels and other pulmonary function parameters or eosinophilic markers.
DISCUSSION AND CONCLUSION: While vitamin D levels did not differ significantly between asthmatic and healthy individuals, a weak positive correlation with PEF% suggests a potential role in improving expiratory flow. No significant association was found with other pulmonary functions or eosinophilic inflammation markers. Further studies are needed to clarify the role of vitamin D in asthma management.

Keywords: Asthma, Eosinophil cationic protein, Immunoglobulin E, Lung function tests, Vitamin D

D vitamini ve ast�m: akci�er fonksiyonu ve eozinofilik inflamasyon ile ili�ki

M�zeyyen Eryilmaz¹, Ilkay Keskinel²
¹�stanbul Sa�l�k Bilimleri �niversitesi, Fatih Sultan Mehmet E�itim ve Ara�t�rma Hastanesi, �� Hastal�klar� Klini�i
²Okan �niversitesi T�p Fak�ltesi, G��s Hastal�klar� Anabilim Dal�

G�R�� ve AMA�: Ast�m, de�i�ken hava ak�m� obstr�ksiyonu ve bron�iyal a��r� duyarl�l�kla karakterize kronik inflamatuar bir hava yolu hastal��d�r. �mmunomod�lat�r etkileri oldu�u bilinen D vitaminin ast�m fizyopatolojisini etkileyebilece�i ve akci�er fonksiyonu ile eozinofilik inflamasyon �zerinde etkili olabilece�i �ne s�r�lmektedir. Bu �al��man�n amac�, ast�ml� hastalar ile sa�l�kl� bireyler aras�ndaki D vitamini d�zeylerindeki farkl�l�klar� ara�t�rmak ve D vitamini ile akci�er fonksiyonu, arteriyel oksijen sat�rasyonu ve eozinofilik inflamasyon belirte�leri aras�ndaki ili�kiyi analiz etmektir.

Y�NTEM ve GERE�LER: Bu retrospektif g�zlemsel �al��ma, Ocak 2022 ile Ocak 2023 tarihleri aras�nda bir e�itim ara�t�rma hastanesinde izlenen 147 ast�ml� hasta ve 30 sa�l�kl� kontrol�n t�bbi kay�tlar�n� incelemi�tir. Akci�er fonksiyon testleri, arteriyel oksijen sat�rasyonu ve eozinofilik belirte�ler (eozinofil say�s�, eozinofil y�zdesi, total IgE ve eozinofil katyonik protein d�zeyleri) analiz edilmi�tir.

BULGULAR: Ast�ml� hastalar ile sa�l�kl� kontroller aras�nda D vitamini d�zeyleri a��s�ndan anlaml� bir fark saptanmam��t�r (p = 0,543). D vitamini d�zeyleri ile tepe ekspiratuar ak�m (PEF)% aras�nda zay�f pozitif bir korelasyon bulunmu�tur (r = 0,185, p = 0,025). D vitamini d�zeyleri ile di�er akci�er fonksiyon parametreleri veya eozinofilik belirte�ler aras�nda anlaml� bir ili�ki g�zlenmemi�tir.

TARTI�MA ve SONU�: D vitamini d�zeyleri ast�ml� ve sa�l�kl� bireyler aras�nda anlaml� �ekilde farkl�l�k g�stermemekle birlikte, PEF% ile g�zlenen zay�f pozitif korelasyon, D vitamininin ekspiratuar ak�m� iyile�tirme potansiyeline i�aret edebilir. Di�er akci�er fonksiyonlar� ve eozinofilik inflamasyon belirte�leri ile anlaml� bir ili�ki saptanmam��t�r. D vitamininin ast�m y�netimindeki rol�n� netle�tirmek i�in daha fazla �al��maya ihtiya� vard�r.

Anahtar Kelimeler: Akci�er fonksiyon testleri, Ast�m, D vitamini, Eozinofil katyonik protein, �mm�noglobulin E

Corresponding Author: Ilkay Keskinel, T�rkiye
Manuscript Language: English

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