ISSN: 2630-5720 | E-ISSN: 2687-346X
The effect of Vitamin D on Interferon-Gamma and Biochemical Parameters in Patients with Metabolic Syndrome [Haydarpasa Numune Med J]
Haydarpasa Numune Med J. 2023; 63(2): 132-136 | DOI: 10.14744/hnhj.2021.58751

The effect of Vitamin D on Interferon-Gamma and Biochemical Parameters in Patients with Metabolic Syndrome

Berna Yücel Aybal1, Süleyman Baş1, Pınar Eker2, Tahsin Aybal1, Ali Ihsan Oluk1, Gülbu Işıtmangil3, Funda Müşerref Türkmen1
1Department of Internal Medicine, University of Health Sciences, Haydarpasa Numune Training and Research Hospital, Istanbul, Türkiye
2Biochemistry Department of Central Laboratory, University of Health Sciences, Istanbul, Türkiye
3Immunology and Tissue Typing Laboratory, University of Health Sciences, Haydarpasa Numune Training and Research Hospital, Istanbul, Türkiye

INTRODUCTION: In this study, the effect of Vitamin D replacement on interferon-gamma (IFN-γ) cytokine and biochemical parameters has been investigated in metabolic syndrome (MetS) patients.
METHODS: The research was planned as a prospective study and included 44 outpatient cases that were selected as MetS according to the IDF-2005 diagnostic criteria without overt diabetes mellitus (DM) or any inflammatory disease. The patients’ Vitamin D level was <30 ng/mL, and their height, waist circumference, weight, and body mass index (BMI) measurements and biochemical parameters were recorded twice before and after 50000 IU Vitamin D replacement for 6 weeks. The IFN-γ levels were measured using the ELISA method and biochemical parameters by enzymatic colorimetric methods according to the manufacturer’s instructions. The data analysis and statistical analyses were performed using IBM SPSS Statistics 22 (IBM SPSS, Türkiye) software.
RESULTS: A statistically significant decrease was noted in the IFN-γ levels of the patients (p<0.001). Furthermore, statistically significant changes were noted in Vitamin D, glucose, calcium, and albumin levels, body weight, and BMI after Vitamin D replacement.
DISCUSSION AND CONCLUSION: The present study reveals that Vitamin D replacement leads to an anti-inflammatory effect on MetS patients as indicated by lower levels of IFN-γ and also a positive effect on hyperglycemia and BMI.

Keywords: Interferon-gamma, metabolic syndrome, vitamin D.

Corresponding Author: Gülbu Işıtmangil, Türkiye
Manuscript Language: English
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