Haydarpasa Numune Med J. 2016; 56(3): 197-200

Anesthesia Management of a Case with Melas Syndrome

Derya Arslan Yurtlu¹, Murat Aksun, Bedriye Özdikiciler, Uður Özgürbüz, Pýnar Ayvat, Gülçin Önder Aran, Mehmet Kýzýlkaya

MELAS syndrome is a disease which delevops as a result of point mutation on mitochondrial level and characterized with mitochondrial
myopathy, lactic acidosis and stroke like episodes. Surgical and anesthesia procedures on MELAS syndrome diagnosed patients exhibites special features since these patients present tendency towards clinical situations such as hypothermia, metabolic acidosis and malign hyperthermia. Syndrome frequently co-exists with diabetes mellitus and cardiac conduction anomalies and this makes the situation more complicated. In this paper, anesthesia management for elective thyroidectomy operation in a MELAS syndrome case with co-existing diabetes mellitus, hypertrophic cardiomyopathy diagnoses is presented and anesthetic approach is discussed.

Keywords: MELAS Syndrome, general anesthesial, lactic acidosis

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Melas Sendromlu Olguda Anestezi Yönetimi

Derya Arslan Yurtlu¹, Murat Aksun, Bedriye Özdikiciler, Uður Özgürbüz, Pýnar Ayvat, Gülçin Önder Aran, Mehmet Kýzýlkaya

MELAS sendromu mitokondrial miyopati, ensefalopati, laktik asidoz ve stroke benzeri epizodlarla karakterize olan mitokondriyal
düzeyde nokta mutasyonu sonucunda geliþen bir hastalýktýr. MELAS sendromu tanýsý olan hastalarda cerrahi ve anestezi uygulamalarý
hastalarýn hipotermi, metabolik asidoz ve malign hipertermi gibi klinik durumlara yatkýn olmalarý nedeniyle özellik oluþturur. Sendromun tablosuna sýklýkla diyabetus mellitus ve kardiyak iletim anomalileri eþlik eder ve durumu daha da karmaþýk hale getirir. Bu yazýda elektif tiroidektomi operasyonu geçiren ve diyabetus mellitus, hipertrofik kardiyomiyopati tanýlarýnýn eþlik ettiði MELAS sendromlu bir olguda anestezi yönetimi sunulmuþ ve anestezik yaklaþým tartýþýlmýþtýr.

Anahtar Kelimeler: MELAS sendromu, genel anestezi, laktik asidoz

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