Evaluation of Inflammatory Hematological Parameters in Cases of Glioblastoma, Primary Cerebral Lymphoma, and Metastasis Following Stereotactic Brain Biopsy

INTRODUCTION: Inflammation and immune reaction are influential both in the etiology and prognosis of many tumors. Inflammatory parameters that can be measured in blood, such as neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and lymphocyte-monocyte ratio, have been found to be associated with the prognosis and course of the disease in many intra and extracranial tumors.
METHODS: Between 2013-2021, lymphocyte, neutrophil, monocyte, and platelet values were measured in the preoperative blood tests of patients diagnosed histopathologically with glial tumors, metastasis, and primary cerebral lymphoma at our clinic through stereotactic biopsy. Ratios of neutrophil-lymphocyte, lymphocyte-monocyte, and platelet-lymphocyte were determined. The values identified in the three tumor groups were statistically compared.
RESULTS: In all three tumor groups, no significant difference was observed in the values of neutrophils, monocytes, and platelets. In the metastasis group, lymphocyte values were significantly higher compared to glial tumor and lymphoma cases. No significant statistical difference was observed in the neutrophil-lymphocyte, lymphocyte-monocyte, and platelet-lymphocyte ratios among the three groups.
DISCUSSION AND CONCLUSION: According to the results of our study, preoperative hematological inflammation parameters do not have a diagnostic or distinguishing effect in glial tumors, metastases, and primary cerebral lymphomas.