ISSN: 2630-5720 | E-ISSN: 2687-346X
[Haydarpasa Numune Med J]
Haydarpasa Numune Med J. 2024; 64(3): 437-439 | DOI: 10.14744/hnhj.2023.70846

High Dose Corticosteroid Therapy for Anti-Thymocyte Globulin Associated Severe Serum Sickness in an Adult Patient with Aplastic Anemia

Murüvvet Seda Aydın1, İsmail Doğan2, Funda Ceran1, Simten Dağdaş1, Gülsüm Özet1
1Department of Hematology, Ankara City Hospital, Ankara, Türkiye
2Department of Rheumatology, Ankara City Hospital, Ankara, Türkiye

Classical serum sickness is a type III immune complex-mediated hypersensitivity disease caused by immunization of the host by non-human serum proteins. Anti-thymocyte globulin is one of the agents mostly responsible. Prophylactic steroids are used in the treatment protocol of aplastic anemia in addition to anti-thymocyte globulin. A 33-year-old female patient diagnosed with aplastic anemia developed severe serum sickness with anti-thymocyte globulin, despite the administration of a prophylactic dose of methylprednisolone. The patient responded dramatically to a single dose of pulse steroid therapy. There are reports that high-dose steroids (1-2 mg/kg/day to 500-1000 mg/day methylprednisolone) and/or therapeutic plasma exchange are beneficial treatment options. Our report shows the benefit of a single pulse dose of steroid and gradual tapering of the dose in this case.

Keywords: Aplastic Anemia, Anti-thymocyte globulin, Immunology, Methylprednisolone, Serum Sickness.

Sorumlu Yazar: Murüvvet Seda Aydın, Türkiye
Makale Dili: İngilizce
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