Haydarpasa Numune Med J. Baskýdaki Makaleler: HNHJ-72246

The Oxidative Stress Level in Children with Inguinal Hernia

Semih Lutfi Mirapoglu¹, Aytekin Kaymakcý², Kubra Bozali³, Eray Metin Guler^4
1Haydarpasa Numune Training and Research Hospital Management, Ýstanbul, Turkey
²Department of Pediatric Surgery, University of Health Sciences Umraniye Training and Research Hospital, Istanbul, Turkey
³Avans University of Applied Science, Faculty Life Sciences and Environmental Technology, Breda, the Netherlands
⁴University of Health Sciences Turkey, Faculty of Hamidiye Medicine, Department of Medical Biochemistry, Istanbul, Turkey

INTRODUCTION: Inguinal hernias (IH) are among the problems frequently encountered by surgeons, and they have the risk of developing significant complications. This study determines the levels of oxidative stress in pediatric patients with inguinal hernia as a case-control study.
METHODS: Inguinal hernina patients who applied to the Bezmialem Vakif University and Health Sciences University Umraniye Health Application and Research Center (SUAM) Pediatric Surgery Outpatient Clinic and healthy control group were studied with the inert blood. Oxidative stress biomarkers total oxidant status (TOS), total antioxidant status (TAS), total thiol (TT), native thiol (NT), and myeloperoxidase (MPO) levels measured by photometric methods. Oxidative stress index (OSI) and disulfide (DIS) were calculated.
RESULTS: Oxidative damage biomarker levels increased statistically in the IH group, TOS, OSI, DIS, and MPO levels (p<0,001). TAS, TT, and NT levels were statistically significantly decreased in the IH group (p<0,001).
DISCUSSION AND CONCLUSION: As a result of our study, while oxidative stress is induced in an inguinal hernia, antioxidant defense is decreased. Our results can guide the determination of the factors that cause inguinal hernia and the development of current treatment.

Keywords: inguinal hernia, oxidative stress, pediatric, thiol-disulfide homeostasis

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