The effect of Vitamin D on Interferon-Gamma and Biochemical Parameters in Patients with Metabolic Syndrome

INTRODUCTION: In this study, the effect of Vitamin D replacement on interferon-gamma (IFN-γ) cytokine and biochemical parameters has been investigated in metabolic syndrome (MetS) patients.
METHODS: The research was planned as a prospective study and included 44 outpatient cases that were selected as MetS according to the IDF-2005 diagnostic criteria without overt diabetes mellitus (DM) or any inflammatory disease. The patients’ Vitamin D level was <30 ng/mL, and their height, waist circumference, weight, and body mass index (BMI) measurements and biochemical parameters were recorded twice before and after 50000 IU Vitamin D replacement for 6 weeks. The IFN-γ levels were measured using the ELISA method and biochemical parameters by enzymatic colorimetric methods according to the manufacturer’s instructions. The data analysis and statistical analyses were performed using IBM SPSS Statistics 22 (IBM SPSS, Türkiye) software.
RESULTS: A statistically significant decrease was noted in the IFN-γ levels of the patients (p<0.001). Furthermore, statistically significant changes were noted in Vitamin D, glucose, calcium, and albumin levels, body weight, and BMI after Vitamin D replacement.
DISCUSSION AND CONCLUSION: The present study reveals that Vitamin D replacement leads to an anti-inflammatory effect on MetS patients as indicated by lower levels of IFN-γ and also a positive effect on hyperglycemia and BMI.