CASPR-2 Antibody-Associated Cramp-Fasciculation Syndrome: A Case Report
Fatma Gülhan Şahbaz1, Rahşan Adviye Inan2, Banu Özen Barut2, Tuğçe Alagöz2, Ahmet Yıldırım3, Simay Başaran11Department of Neurology, İzmir University of Economics Medical Point Hospital, İzmir, Türkiye2Department of Neurology, University of Health Sciences, Istanbul Kartal Dr. Lütfi Kırdar City Hospital, İstanbul, Türkiye
3Department of Neurology, University of Medeniyet, Göztepe City Hospital, İstanbul, Türkiye
Cramp-fasciculation syndrome is a rare form of peripheral nerve hyperexcitability (PNH). We report the case of a 79-year-old man who presented with widespread, visible, and persistent muscle twitching involving both upper and lower limbs, more prominently affecting the entire body, accompanied by a burning sensation in the feet for approximately 1 month. He also reported difficulty initiating sleep and frequent constipation. Clinical and electrophysiological evaluations demonstrated fasciculations and cramps. Further investigations identified positive contactin-associated protein-like 2 antibodies, a subtype of voltage-gated potassium channel antibodies, as the underlying etiology. Although fasciculations are commonly seen in motor neuron diseases and radiculopathies, they may also appear, though less frequently, as part of a PNH syndrome. Clinically, this condition represents a spectrum disorder, and autoimmune mechanisms are often implicated in its pathogenesis.
Keywords: Autoimmune, cramp, fasciculation.
Manuscript Language: English