Two Cases With Benign Transient Hyperphosphatemia

Aky�z �zkan, Esra; H�srev�ahi, Ha�im; Ya�ar, Adem; Ge�it, U. Aliye

Two Cases With Benign Transient Hyperphosphatemia [Haydarpasa Numune Med J]

Haydarpasa Numune Med J. 2016; 56(3): 201-204

Two Cases With Benign Transient Hyperphosphatemia

Esra Aky�z �zkan¹, Ha�im H�srev�ahi², Adem Ya�ar¹, U. Aliye Ge�it¹
¹Department of Pediatrics, Bozok University Faculty of Medicine, Yozgat, Turkey
²Department of Pediatric Cardiology, Bozok University Faculty of Medicine, Yozgat, Turkey

Bening transient hyperphosphatasemia is a clinic status seen in children generally younger than 5 years and characterized by serum
alkaline phosphate (ALP) level higher than 3-50 times above the normal without evidence of liver and bone disease. The high alkaline phosphates level turn normal in 2-6 month. This article presents two cases that diagnosed elevated alkaline phosphate levels during routine tests, turn to normal spontaneously and had no liver and bone diseases. It is thought that this high level is due to viral infection. Benign transient hyperphosphatasemia is a condition that benign, transient and self limited. In the event of isolated high levels of ALP without clinical and laboratory findings, transient hyperphosphatasemia should be considered in the differential diagnosis. Patient can also be followed up in general pediatric clinics without referring to another center and performing unnecessary, richer tests.

Keywords: Alkaline phosphate, benign transient hyperphosphatasemia, child, viral infection

Ge�ici Benign Hiperfosfatazemili �ki Olgu

Esra Aky�z �zkan¹, Ha�im H�srev�ahi², Adem Ya�ar¹, U. Aliye Ge�it¹
¹Bozok �niversitesi T�p Fak�ltesi, Pediatri Anabilim Dal�, Yozgat
²Bozok �niversitesi T�p Fak�ltesi, Pediatrik Kardiyoloji Anabilim Dal�, Yozgat

Benign ge�ici hiperfosfatazemi �o�unlukla 5 ya��ndan k��k �ocuklarda serum alkalen fosfataz d�zeyinin karaci�er ve kemik hastal��
olmaks�z�n normal de�erlerin 3-50 kat y�kselmesiyle karakterize bir klinik durumdur. Alkalen fosfataz d�zeyleri 2-6 ay i�inde kendili�inden normale d�nmektedir. Bu yaz�da rutin tetkikler s�ras�nda ALP d�zeyinde y�kseklik saptanan, takiplerinde kendili�inden normale d�nen, karaci�er ve kemik hastal�� bulunmayan ve bu y�ksekli�in sebebinin viral enfeksiyonlara ba�l� benign ge�ici hiperfosfatazemi oldu�u d��n�len iki olgu sunulmu�tur. Benign ge�ici hiperfosfatazemi benign, ge�ici ve kendini s�n�rlayabilen bir durumdur. Klinik ve laboratuar bulgusu olmadan izole ALP y�ksekli�i durumunda, ge�ici hiperfosfatemi ay�r�c� tan�da mutlaka ak�lda tutulmal�d�r. Bu hastalar gereksiz ve pahal� testlere gerek kalmadan ve ileri bir merkeze sevk edilmeden genel �ocuk polikliniklerinde izlenebilirler.

Anahtar Kelimeler: Alkalen fosfataz, benign ge�ici hiperfosfatazemi, �ocuk, viral enfeksiyon

Corresponding Author: Esra Aky�z �zkan, T�rkiye
Manuscript Language: Turkish

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