Synchronous Endometrial and Ovarian Carcinomas; Correlation of Clinicopathological Parameters with Recurrence and Survival

INTRODUCTION: We aimed to determine the possible clinicopathological factors that might affect recurrence and survival in synchronous malignancy of the endometrium and ovary without discriminating the presence of two independent primary tumors or metastasis.
METHODS: Patients who were admitted with the diagnosis of synchronous endometrial and ovarian cancer between 2000 and 2015 were reviewed retrospectively.
RESULTS: Recurrence occurred in 12 (48%) patients. The mean duration of recurrence was 23.7 months. There is a significant relationship between presence of lenfovascular invasion), involvement of lymph node, spread to non-ovarian, and non-endometrial pelvic organs or beyond and the increase recurrence risk in the synchronous endometrial and ovarian cancer. The conditions involving the increased diameter of tumor in the endometrium and bilateral ovarian involvement are related with decreased survival. Besides, presence of endometrioid type ovarian tumor and absence of endometrial myometrial invasion are related with increased survival.
DISCUSSION AND CONCLUSION: Variables such as endometrial tumor diameter, myometrial invasion, endo/non endo type of ovarian tumor and presence of bilateral tumor were found to be effective on survival, variables such as lymphovascular invasion, lymph node involvement, and pelvic spread were effective on recurrence.