ISSN: 2630-5720 | E-ISSN: 2687-346X
The Effect of 25-OH Vitamin D on Biochemical and IL-12 Parameters in Patients with Metabolic Syndrome [Haydarpasa Numune Med J]
Haydarpasa Numune Med J. 2022; 62(4): 434-439 | DOI: 10.14744/hnhj.2021.10846

The Effect of 25-OH Vitamin D on Biochemical and IL-12 Parameters in Patients with Metabolic Syndrome

Ali Ihsan Oluk1, Sülayman Baş1, Pınar Eker2, Berna Yücel Aybal1, Gülbu Işıtmangil3, Funda Türkmen1
1Department of Internal Medicine of Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye
2Department of Biochemistry Department of Central Laboratory of Anatolia North Public Hospitals, Istanbul, Türkiye
3Immunology and Tissue Typing Laboratory, University of Health Sciences, Haydarpasa Numune Training and Research Hospital, Istanbul, Türkiye

INTRODUCTION: The present study investigates the effect of 25-OH vitamin D replacement on blood pressure, as well as biochemical and IL-12 parameters in patients with metabolic syndrome (MetS), and whether a threshold for vitamin D exists in such effect.
METHODS: This prospective study included 44 metabolic syndrome patients who presented to the Internal Medicine Clinic of Haydarpaşa Numune Training and Research Hospital. The patients had a mean age of 44.68±11.49 years; 65.9% (n=29) were female and 34.1% (n=15) were male. Biochemical tests were made for 25-OH vitamin D, glucose, HbA1c, triglycerides, HDL-K, LDL-K, BUN, creatinine, uric acid, calcium, albumin, leukocytes, neutrophils, lymphocytes, hemoglobin, C-reactive protein, and spot urine albumin/creatinine ratio, and blood pressure measurements were made before and after vitamin D replacement. In addition, IL-12 levels were measured twice using the ELISA method. A statistical analysis of the data was made using IBM the SPSS Statistics 22 (IBM SPSS, Türkiye) software package.
RESULTS: A statistically significant decrease was noted in systolic and diastolic blood pressure and IL-12 levels after vitamin D re-placement when compared to the pre-replacement levels (p<0.001, p=0.008, p<0.001). When the patients were divided into two groups based on 25-OH vitamin D levels (Group-1, 25-OH vitamin D ≥32 ng/mL; Group-2, 25-OH vitamin D <32 ng/mL) after vitamin D replacement, the mean IL-12 level was found to be significantly lower in the Group-1 patients than in the Group-2 patients (p<0.033). In addition, a positive correlation was identified between vitamin D replacement and serum levels of magnesium.
DISCUSSION AND CONCLUSION: These findings suggested that vitamin D replacement had blood pressure-lowering and anti-inflammatory effects in MetS patients. The threshold for the anti-inflammatory effect was found to be ≥32 ng/mL.

Keywords: Inflammation, metabolic syndrome, Vitamin D.

Ali Ihsan Oluk, Sülayman Baş, Pınar Eker, Berna Yücel Aybal, Gülbu Işıtmangil, Funda Türkmen. The Effect of 25-OH Vitamin D on Biochemical and IL-12 Parameters in Patients with Metabolic Syndrome. Haydarpasa Numune Med J. 2022; 62(4): 434-439

Corresponding Author: Gülbu Işıtmangil, Türkiye
Manuscript Language: English
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