Epilepsy and Pregnancy: Retrospective Analysis of 58 Cases
Koray Gök1, Erdal Yılmaz1, Asude Özgül1, Nazife Reyyan Gök2, Mehmet Suhha Bostancı1, Selçuk Özden11Department of Obstetrics and Gynecology, Sakarya University Faculty of Medicine, Sakarya, Turkey2Department of Pediatrics, Division of Neonatology, Istanbul Health Sciences University Umraniye Training and Research Hospital, Istanbul, Turkey
INTRODUCTION: This study aimed to retrospectively evaluate the perinatal outcomes of pregnant women diagnosed with epilepsy followed in our clinic.
METHODS: In this retrospective cohort study, a total of 58 pregnant women diagnosed with epilepsy who were delivered after pregnancy follow-up at Sakarya University Training and Research Hospital Gynecology and Obstetrics Clinic between January 2015 and March 2021 were evaluated.
RESULTS: The mean age of the patients was 28.4±5.7 years. It was determined that 25 cases (43.1%) had seizures during pregnancy. It was determined that the rate of seizures during pregnancy in those who had a seizure in the past 1 year before pregnancy was statistically significantly higher than those who had their last seizure longer than 1 year (p=0.000). It was found that 72.7% of the patients in the polytherapy group had epileptic seizures during pregnancy, and this rate was significantly higher than the monotherapy group (p=0.042).
DISCUSSION AND CONCLUSION: The frequency of seizures during pregnancy is strongly associated with epileptic seizure status in the last year before pregnancy and multiple antiepileptic therapies.
Manuscript Language: English