New Indicator of Inflammation in Migraine: Red Blood Cell Distribution

G�l, Zeynep Bastu�; �elik, Rabia G�kcen G�z�bat�k; Sel�uk, Batuhan; Aksoy, Sena; G�l, Mehmet; Soysal, Aysun

New Indicator of Inflammation in Migraine: Red Blood Cell Distribution [Haydarpasa Numune Med J]

Haydarpasa Numune Med J. 2021; 61(2): 166-171 | DOI: 10.14744/hnhj.2021.46872

New Indicator of Inflammation in Migraine: Red Blood Cell Distribution

Zeynep Bastu� G�l¹, Rabia G�kcen G�z�bat�k �elik¹, Batuhan Sel�uk¹, Sena Aksoy¹, Mehmet G�l², Aysun Soysal¹
¹Department of Neurology, University of Health Sciences Turkey, Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatric, Neurologic and Neurosurgical Diseases, Istanbul, Turkey
²Department of Cardiology, University of Health Sciences Turkey, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey

INTRODUCTION: The role of inflammation in the pathophysiology of migraine is controversial. We aimed to investigate new inflammatory markers such as red blood cell distribution width (RDW) and plateletcrit in patients with migraine.
METHODS: In this study, 100 patients suffering from migraine and 67 healthy controls with similar demographic characteristics were included in the study. Complete blood count (CBC) including number of neutrophils, lymphocytes and platelets, RDW, plateletcrit, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fasting blood glucose, serum creatinine, and neutrophil-to-lymphocyte ratio (NLR) was compared between these two groups. SPSS was used for statistical analysis.
RESULTS: There was positive correlation between RDW and migraine group, CRP, plateletcrit, platelet, and neutrophil counts. The results of ESR, platelet count and RDW in migraine group were higher than control group significantly (p=0.044, p=0.024, and p=0.002, respectively). CRP, NLR, and plateletcrit were higher in migraine group without significance. In multivariate analysis, RDW was found as a significant independent predictor of migraine after adjusting for other risk factors (p=0.048). In a receiver operating characteristic curve analysis, an RDW value of 13.25% was identified as an effective cutoff point for migraine (area under curve = 0.620, 95% confidence interval: 0.53�0.71, p=0.009). An RDW value of more than 13.25% yielded a sensitivity of 58% and a specificity of 54%.
DISCUSSION AND CONCLUSION: In our study, we found that RDW was higher in patients with migraine than control group, independent of other variables. RDW can be used as an inflammatory marker for migraine with a simple and inexpensive CB examination.

Keywords: C-reactive protein, inflammation; migraine disorders.

Migrende Yeni Enflamasyon G�stergesi: K�rm�z� Kan H�cresi Da��l�m�

Zeynep Bastu� G�l¹, Rabia G�kcen G�z�bat�k �elik¹, Batuhan Sel�uk¹, Sena Aksoy¹, Mehmet G�l², Aysun Soysal¹
¹Sa�l�k Bilimleri �niversitesi, N�roloji Anabilim Dal�, Bak�rk�y Prof. Dr. Mazhar Osman Psikiyatri, N�rolojik ve N�ro�ir�rji Hastal�klar� E�itim Ve Ara�t�rma Hastanesi, �stanbul, T�rkiye.
²�stanbul Mehmet Akif Ersoy G��s Kalp Damar Cerrahisi E�itim ve Ara�t�rma Hastanesi, Kardiyoloji Klini�i, Sa�l�k Bilimleri �niversitesi, �stanbul, T�rkiye

G�R�� ve AMA�: Migren patofizyolojisinde inflamasyonun rol� tart��mal�d�r. Migren hastalar�nda k�rm�z� kan h�cresi da��l�m geni�li�i (RDW) ve plateletkrit gibi yeni inflamatuar belirte�leri ara�t�rmay� ama�lad�k
Y�NTEM ve GERE�LER: Bu �al��maya 100 migren hastas� ve benzer demografik �zelliklere sahip 67 sa�l�kl� kontrol dahil edildi. N�trofil, lenfosit ve trombosit say�s�, RDW, plateletkrit, eritrosit sedimantasyon h�z� (ESR), C-reaktif protein (CRP), a�l�k kan �ekeri, serum kreatinin, n�trofil-lenfosit oran� (NLR) dahil olmak �zere tam kan say�m� (CBC) bu iki grup aras�nda kar��la�t�r�ld�. �statistiksel analiz i�in SPSS kullan�ld�.
BULGULAR: RDW ile migren grubu, CRP, plateletkrit, trombosit ve n�trofil say�lar� aras�nda pozitif korelasyon vard�. Migren grubunda ESR, trombosit say�s� ve RDW sonu�lar� kontrol grubuna g�re anlaml� olarak y�ksekti (s�ras�yla p = 0,044, p = 0,024, p = 0,002). CRP, NLR ve platelekrit, migren grubunda anlaml� olmaks�z�n daha y�ksekti. �ok de�i�kenli analizde, RDW, di�er risk fakt�rlerine g�re ayarland�ktan sonra migrenin anlaml� ba��ms�z �ng�r�c�s� olarak bulundu (p=0,048). Receiver Operating Characteristics (ROC) e�risi analizinde, %13.25'lik bir RDW de�eri migren i�in etkili bir kesme noktas� olarak tan�mlanm��t�r (e�ri alt�ndaki alan = 0.620, % 95 CI: 0.53-0.71, p=0,009). % 13.25'in �zerindeki bir RDW de�eri, %58'lik bir duyarl�l�k ve %54'l�k bir �zg�ll�k sa�lam��t�r.
TARTI�MA ve SONU�: �al��mam�zda, migrenli hastalarda RDW'nin di�er de�i�kenlerden ba��ms�z olarak kontrol grubuna g�re daha y�ksek oldu�unu bulduk. RDW, basit ve ucuz bir tam kan say�m� incelemesi olarak migren i�in enflamatuar bir belirte� olarak kullan�labilir.

Anahtar Kelimeler: Migren hastal�klar�, inflamasyon, C-reaktif protein

Corresponding Author: Zeynep Bastu� G�l, T�rkiye
Manuscript Language: English

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