Haydarpasa Numune Med J. Ahead of Print: HNHJ-76476 | DOI: 10.14744/hnhj.2021.76476

Synchronous Endometrial and Ovarian Carcinomas; Correlation of Clinicopathological Parameters with Recurrence and Survival

Nermin Koc¹, Sevcan Arzu Arinkan², Davut Þahin³, OSMAN TEMIZKAN^4
1Department of Pathology, Haydarpasa Numune Research and Training Hospital, Istanbul, Turkey
²Department of Obstetrics and Gynecology, Haydarpasa Numune Research and Training Hospital, University of Health Sciences, Istanbul, Turkey
³Department of Pathology, Acibadem International Medical Center, Istanbul, Turkey
⁴Department of Obstetrics and Gynecology, Acibadem International Medical Center, Istanbul, Turkey

INTRODUCTION: We aimed to determine the possible clinicopathological factors that might affect recurrence and survival in synchronous malignancy of the endometrium and ovary without discriminating the presence of two independent primary tumors or metastasis.
METHODS: Patients who were admitted with the diagnosis of synchronous endometrial and ovarian cancer between 2000 and 2015 were reviewed retrospectively.
RESULTS: Recurrence occurred in 12 (48%) patients. The mean duration of recurrence was 23.7 months. There is a significant relationship between presence of LVI (lenfovascular invasion), involvement of lymph node, spread to non-ovarian and non-endometrial pelvic organs or beyond and the increase recurrence risk in the synchronous endometrial and ovarian cancer. The conditions involving the increased diameter of tumor in the endometrium and bilateral ovarian involvement are related with decreased survival. Besides, presence of endometrioid type ovarian tumor and absence of endometrial myometrial invasion are related with increased survival.
DISCUSSION AND CONCLUSION: Variables such as endometrial tumor diameter, myometrial invasion, endo / nonendo type of ovarian tumor and presence of bilateral tumor were found to be effective on survival, variables such as lymphovascular invasion, lymph node involvement, and pelvic spread were effective on recurrence.

Keywords: Endometrium cancer, ovarian cancer, recurrence, synchronous, survival

---

Senkron Over ve Endometrium Tümörlerinde Nüks ve Sað Kalýmý Etkileyen Klinikopatolojik Faktörlerin Deðerlendirilmesi

Nermin Koc¹, Sevcan Arzu Arinkan², Davut Þahin³, OSMAN TEMIZKAN^4
1Haydarpaþa Numune Eðitim ve Araþtýrma Hastanesi, Patoloji Kliniði, Ýstanbul
²Saðlýk Bilimleri Üniversitesi, Haydarpaþa Numune Eðitim ve Araþtýrma Hastanesi, Kadýn Hastalýklarý ve Doðum Kliniði, Ýstanbul
³Acýbadem Hastanesi, Patoloji Bölümü, Ýstanbul
⁴Acýbadem Hastanesi, Kadýn Hastalýklarý ve Doðum Bölümü

GÝRÝÞ ve AMAÇ: Bu çalýþma ile senkron over ve endometrium tümörlerinde sað kalým ve nükse etki edecek klinikopatolojik faktörleri araþtýrmayý amaçladýk.
YÖNTEM ve GEREÇLER: 2000 ile 2015 yýllarý arasýnda senkron endometrium ve over kanseri sebebiyle ameliyat olan hastalarýn bilgilerini retrospektif olarak deðerlendirdik.
BULGULAR: Olgularýn %48’inde (n=12) nüks izlendi ve ortalama nüks süresi 23,7 ay idi. Lenfovasküler invazyon, lenf nodu tutulumu, over ve endoemtrium dýþý pelvik organlara yayýlým ile nüks arasýnda belirgin iliþki saptandý. Endometriumdaki tumör boyutu ve bilateral overyan tutulum azalmýþ sað kalým ile iliþkili bulundu. Ayrýca, endometrioid tip ovaryen tümör ve myometriyal invazyon olmamasý ile artmýþ sað kalým arasýnda iliþki saptandý.
TARTIÞMA ve SONUÇ: Endometrial tümör çapý, myometriyal invazyon, endo / nonendo tipte over tumörü ve bilateral tumör varlýðý gibi deðiþkenlerin sað kalým üzerinde etkili olduðu, lenfovasküler invazyon, lenf nodu tutulumu ve pelvik yayýlým gibi deðiþkenlerin nüks üzerinde etkili olduðu bulundu.

Anahtar Kelimeler: Endometrium kanseri, over kanseri, nüks, sað kalým

---