Haydarpasa Numune Med J. 2022; 62(1): 82-86 | DOI: 10.14744/hnhj.2022.34654

Evaluation of Perinatal Outcomes in Intrahepatic Cholestasis of Pregnancy

Koray Gök¹, Asude Özgül¹, Erdal Yýlmaz¹, Nazife Reyyan Gök², Mehmet Sühha Bostancý¹, Selçuk Özden^1
1Department of Obstetrics and Gynecology, Sakarya University Faculty of Medicine, Sakarya, Turkey
²Department of Pediatrics, Division of Neonatology, Istanbul Health Sciences University Umraniye Training and Research Hospital, Istanbul, Turkey

INTRODUCTION: This study aimed to retrospectively evaluate the perinatal outcomes of the cases followed up in our clinic for Intrahepatic cholestasis of pregnancy (ICP).
METHODS: In this study, the medical records of 71 patients who applied to Sakarya University Training and Research Hospital, Gynecology and Obstetrics Clinic between April 2015 and March 2021 and were diagnosed with ICP were analyzed retro-spectively.
RESULTS: The mean age of the patients was 28.9±4.8 years. At the time of diagnosis, the mean week of gestation was 31.9±2.4 weeks, and the mean week of gestation at birth was 36.7±1.5 weeks. It was determined that 20 (28.2%) of the patients had preterm birth before 37 weeks of gestation. The gestational week at the time of diagnosis was found to be statistically signifi-cantly lower in patients who had preterm birth (30.5±1.7) compared to those who did not (32±2.5) who did not have preterm birth (p: 0.025). When the correlation analysis was performed, a statistically significant negative correlation was found between the gestational week at the time of diagnosis and preterm birth (p=0.024, r=−0.268).
DISCUSSION AND CONCLUSION: Although ICP is a benign condition for the mother, it can cause significant complications in the fetus. Therefore, early diagnosis and active management are essential in reducing adverse complications related to ICP.

Keywords: Intrahepatic cholestasis, perinatal outcomes, pregnancy.

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Gebeliðin Ýntrahepatik Kolestazýnda Perinatal Sonuçlarýn Deðerlendirilmesi

Koray Gök¹, Asude Özgül¹, Erdal Yýlmaz¹, Nazife Reyyan Gök², Mehmet Sühha Bostancý¹, Selçuk Özden^1
1Sakarya Üniversitesi Týp Fakültesi Kadýn Hastalýklarý ve Doðum Anabilim Dalý, Sakarya, Türkiye
²Ýstanbul Saðlýk Bilimleri Üniversitesi Ümraniye Eðitim ve Araþtýrma Hastanesi, Çocuk Saðlýðý ve Hastalýklarý Anabilim Dalý, Neonatoloji Anabilim Dalý, Ýstanbul, Türkiye

GÝRÝÞ ve AMAÇ: Bu çalýþmada, kliniðimizde Gebeliðin Ýntrahepatik Kolestazý (GÝK) nedeniyle takip edilen olgularýn perinatal sonuçlarýný retrospektif olarak deðerlendirmeyi amaçladýk.
YÖNTEM ve GEREÇLER: Bu çalýþmada, Nisan 2015-Mart 2021 tarihleri arasýnda Sakarya Üniversitesi Eðitim ve Araþtýrma Hastanesi Kadýn Hastalýklarý ve Doðum Kliniði'ne baþvuran ve Gebeliðin Ýntrahepatik Kolestazý (GÝK) tanýsý konulan 71 hastanýn týbbi kayýtlarý retrospektif olarak incelendi.
BULGULAR: Hastalarýn yaþ ortalamasý 28.9 ± 4.8 idi. Taný anýndaki ortalama gebelik haftasý 31.9 ± 2.4 hafta ve doðumdaki ortalama gebelik haftasý 36.7 ± 1.5 hafta idi. Hastalarýn 20’sinin (%28.2) 37. gebelik haftasýndan önce preterm doðum yaptýðý saptandý. Taný anýndaki gebelik haftasý preterm doðum yapanlarda (30.5 ± 1.7) preterm doðum yapmayanlara (32 ± 2.5) göre istatistiksel olarak anlamlý derecede küçük saptandý (p: 0.025). Korelasyon analizi yapýldýðýnda, taný anýndaki gebelik haftasý ile preterm doðum arasýnda istatistiksel olarak anlamlý derecede negatif yönde korelasyon saptandý (p: 0.024, r: -0.268).
TARTIÞMA ve SONUÇ: GÝK, her ne kadar anne için benign bir durum olsa da fetüste önemli komplikasyonlara yol açabilmektedir. Bu nedenle, erken taný ve aktif yönetim, GÝK ile ilgili olumsuz komplikasyonlarý azaltmada esastýr.

Anahtar Kelimeler: Ýntrahepatik kolestaz, gebelik, perinatal sonuçlar.

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