Monocyte High-Density Lipoprotein Cholesterol Ratio and Coronary Collateral Circulation Development in Patients with Stable Coronary Artery Disease and no History of Revascularization

INTRODUCTION: In patients with chronic total occlusion (CTO), various degrees of coronary collateral circulation (CCC) can be seen. No clinical study was conducted for the relationship between monocyte/high-density lipoprotein cholesterol ratio (MHR) and the development of CCC.
METHODS: Among 17,391 patients, the angiographic procedures were analyzed. Patients who had a history of acute coronary syndrome, myocardial infarction, percutaneous coronary intervention (PCI), or coronary artery bypass graft (CABG) procedure were excluded from the study. A total of 217 patients with CTO were retrospectively analyzed. The Cohen-Rentrop classification was used for retrograde CCC score.
RESULTS: Both patient groups were male dominant. The prevalence of hypertension and diabetes was similar. MHR values did not differ between poor CCC versus good CCC groups (13.90±6.34 vs. 14.33±7.57, respectively, p=0.948). About 15.5% of patients in the poor CCC group and 19.9% of patients in the good CCC group have multiple CTOs.
DISCUSSION AND CONCLUSION: MHR as a novel marker of inflammation and atherosclerotic index is not related to CCC development in patients with CTO and stable coronary artery disease.