The Oxidative Stress Level in Children with Inguinal Hernia
Semih Lütfi Mirapoğlu1, Aytekin Kaymakcı2, Kübra Bozali3, Eray Metin Güler41Department of Pediatric Surgery, University of Health Sciences Turkey Umraniye Training and Research Hospital, Istanbul, Türkiye2Haydarpasa Numune Training and Research Hospital Chief Physician, İstanbul, Türkiye
3Avans University of Applied Science, Faculty Life Sciences and Environmental Technology, Breda, the Netherlands; Department of Medical Biochemistry, University of Health Sciences Turkey, Faculty of Hamidiye Medicine, Istanbul, Türkiye
4Department of Medical Biochemistry, University of Health Sciences Turkey, Faculty of Hamidiye Medicine, Istanbul, Türkiye; Department of Medical Biochemistry, University of Health Sciences Turkey Haydarpasa Numune Training and Research Hospital, Istanbul, Türkiye
INTRODUCTION: Inguinal hernias (IH) are among the problems frequently encountered by surgeons, and they have the risk of developing significant complications. This study determines the levels of oxidative stress in pediatric patients with IH as a case–control study.
METHODS: Inguinal hernia patients who applied to the Bezmialem Vakif University and Health Sciences University Umraniye Health Application and Research Center Pediatric Surgery Outpatient Clinic and healthy control group were studied with the inert blood. Oxidative stress biomarkers total oxidant status (TOS), total antioxidant status (TAS), total thiol (TT), native thiol (NT), and myeloperoxidase (MPO) levels measured by photometric methods. Oxidative stress index (OSI) and disulfide (DIS) were calculated.
RESULTS: Oxidative damage biomarker levels increased statistically in the IH group, TOS, OSI, DIS, and MPO levels (p<0.001). TAS, TT, and NT levels were statistically significantly decreased in the IH group (p <0.001).
DISCUSSION AND CONCLUSION: As a result of our study, while oxidative stress is induced in an IH, antioxidant defense is decreased. Our results can guide the determination of the factors that cause IH and the development of current treatment.
Corresponding Author: Eray Metin Güler, Türkiye
Manuscript Language: English