Haydarpasa Numune Med J. 2022; 62(1): 87-92 | DOI: 10.14744/hnhj.2020.82713

Ameliyat Öncesi Kan Enflamatuar Belirteçleri Açýsýndan Tipik ve Atipik Hipokampal Skleroz Arasýnda Bir Fark Var mý?

Rahsan Kemerdere¹, Oðuz Baran², Orkhan Alizada¹, Sureyya Toklu¹, Mehmet Yiðit Akgun¹, Seher Naz Yeni³, Taner Tanriverdi^1
1Nöroþirürji Anabilim Dalý, Týp Fakültesi, Ýstanbul Üniversitesi-Cerrahpaþa, Ýstanbul, Türkiye
²Haseki Eðitim ve Araþtýrma Hastanesi Nöroþirürji Anabilim Dalý, Ýstanbul, Türkiye
³Nöroloji Anabilim Dalý, Týp Fakültesi, Ýstanbul Üniversitesi-Cerrahpaþa, Ýstanbul, Türkiye

GÝRÝÞ ve AMAÇ: Bu retrospektif çalýþmanýn amacý ameliyat öncesi inflamatuvar belirteçlerin tipik ve atipik hipokampal sklerozlu (HS) hastalarda farkýnýn ortaya konmasýdýr.
YÖNTEM ve GEREÇLER: Bu amaçla çalýþmaya, ilaca dirençli temporal lob epilepsi nedeniyle ameliyat edilen 44 hasta dahil edilmiþtir. Ameliyat öncesi elde edilen hemogram sonuçlarýndan nötrofil, lenfosit, monosit, platelet sayýlarý ve nötrofil-lenfosit oraný, platelet-lenfosit oraný, lenfosit-monosit oraný ve sistemik-inflamasyon indeksi hesaplanmýþtýr.
BULGULAR: Tipik HS hastalarýnda atipik HS hastalarýna göre inflamatuvar belirteçlerin çoðu yüksek seviyede bulunsa da anlamlý fark saptanmamýþtýr. Belirteçlerin hiçbiri nöronal kayýp ile korelasyon göstermemiþtir.
TARTIÞMA ve SONUÇ: Tipik ve atipik HS hastalarý arasýnda fark olmasa da, bazý inflamatuvar belirteçlerin atipik HS hastalarýna göre nöronal kaybýn ciddi olduðu tipik HS hastalarýnda yükselme eðilimi gösterdiði saptandý. Daha fazla hasta satýsýný içeren retrospektif and tercihen prospektik ileri çalýþmalara ihtiyaç vardýr.

Anahtar Kelimeler: Epilepsi, Hipokampal skleroz, Ýnflamasyon, Ýnflamatuvar belirteç, Temporal lob epilepsi.

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Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?

Rahsan Kemerdere¹, Oðuz Baran², Orkhan Alizada¹, Sureyya Toklu¹, Mehmet Yiðit Akgun¹, Seher Naz Yeni³, Taner Tanriverdi^1
1Department of Neurosurgery, Medical Faculty, Istanbul University-Cerrahpaþa, Istanbul, Turkey
²Department of Neurosurgery, Haseki Research and Training Hospital, Istanbul, Turkey
³Department of Neurology, Medical Faculty, Istanbul University-Cerrahpaþa, Istanbul, Turkey

INTRODUCTION: The purpose of this retrospective study was to provide whether there was a difference regarding pre-opera-tive inflammatory markers between typical and atypical hippocampal sclerosis (HS).
METHODS: For this purpose, 44 patients who underwent epilepsy surgery due to drug-resistant temporal lobe epilepsy were included. Pre-operative neutrophil, lymphocyte, monocyte, and platelet counts as well as neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, lymphocyte-monocyte ratio, and systemic immune-inflammation index) were noted from pe-ripheral blood tests.
RESULTS: Although the majority of inflammatory markers showed higher levels in typical HS, no significant differences were found. None of the markers studied showed a correlation with the degree of neuronal loss.
DISCUSSION AND CONCLUSION: Although no differences between typical and atypical HS were demonstrated, there was a trend to increase in the levels of some inflammatory markers in typical HS which is severe form of neuronal loss compared to atypical HS and further studies with larger cohort of retrospective and preferably prospective are needed.

Keywords: Epilepsy, hippocampal sclerosis, inflammation, inflammatory marker, temporal lobe epilepsy.

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