ISSN: 2630-5720 | E-ISSN: 2687-346X
HAYDARPAŞA NUMUNE MEDICAL JOURNAL - Haydarpasa Numune Med J: 61 (2)
Volume: 61  Issue: 2 - 2021
1. Cover

Page I

2. Editorial Board

Pages II - III

3. Contents

Pages IV - V

RESEARCH ARTICLE
4. Evaluation of Cases Applied to Emergency Service with Suspected Rabies Exposure in the Past Year
Davut Tekyol, Şahin Çolak, İsmail Tayfur, Ayşe Yüksel, Abdullah Algın, Nihat Mujdat Hokenek, İbrahim Altundağ, Tuğçe Zengin
doi: 10.14744/hnhj.2019.83723  Pages 123 - 126
INTRODUCTION: Rabies is a zoonosis that can be transmitted by contact with an infected animal and results in death. Dog bites are the most common cause of human deaths. In this study, cases who applied to the emergency service of a training and research hospital in Istanbul due to suspected rabies exposure in the past year were examined. Our aim is to provide recommendations for reducing the need for prophylaxis after suspected exposure.
METHODS: Patients who presented to the emergency department due to suspected rabies exposure between September 2017 and August 2018 were included in the study. Data were obtained by examining the emergency service files of the patients and the records kept by the hospital’s rabies treatment unit. The number of cats and dogs causing suspected exposure were compared with similar studies. p<0.01 was accepted for statistical significance.
RESULTS: A total of 10,974 cases applied due to suspected exposure within the time period stated above. About 50.1% (n=5493) of the cases were male and 49.9% (n=5481) were female. While the most suspected contacts were caused by cats (64.1%) and dogs (35.2%), the exposure was highest in summer and least in winter. Only rabies vaccine was administered to 87.2% of the cases admitted to the emergency service, and vaccine and immunoglobulin were administered to 9.1% of the cases. As a result of these suspected rabies exposures, no death and limb amputation were detected, while six cases had saturation.
DISCUSSION AND CONCLUSION: It is seen that the ratio of cats to dogs in suspected rabies exposure has increased, compared to previous years. Vaccination, sterilization, and registration of animals that can cause rabies, making appropriate markings that clearly show that the animals have been vaccinated, and raising the public awareness on this issue can reduce the need for post-exposure vaccination.

5. Ideal Cardiovascular Health by Gender in Cardiology Outpatients: A Cross-Sectional Study
Evrin Dağtekin, Gökçe Dağtekin, Selma Metintaş
doi: 10.14744/hnhj.2019.36349  Pages 127 - 133
INTRODUCTION: Ideal cardiovascular health (ICH) has defined to reduce cardiovascular disease and to improve health by 2020. The aim was to evaluate ICH and recurrence of myocardial infarctions by gender in cardiology outpatients.
METHODS: The questionnaire form was applied by face-to-face interviews method by researchers. It was used American Heart Association definitions to determine the cardiovascular risk factors and ICH. Having each risk factor was defined as 1 point. According to this, the total cardiovascular health score calculated ranged from 0 to 7. It is considered statistically significant if p≤0.05.
RESULTS: The ages of 261 participants of the study group ranged between 18 and 83, the mean age ± standard deviation (SD) was 50.68±15.39 years in the entire study group, 51.03±15.17 years in men and 50.44±15.58 years in women (p>0.05). The ICH status among the participants was found to be 4.6%. In the study, in both sexes there was a moderate positive correlation between the total cardiovascular health score and the number of experienced myocardial infarctions.
DISCUSSION AND CONCLUSION: ICH frequency was found to be very low in both sexes. Furthermore, ICH score was associated with myocardial infarction recurrences in both sexes.

6. Laparoscopic Interventions for Hiatal Hernia: Analysis of 51 Consecutive Cases
Abdullah Yıldız, Hanife Şeyda Ülgür, Sırma Mine Tilev
doi: 10.14744/hnhj.2019.53496  Pages 134 - 138
INTRODUCTION: Studies on the detection of benign causes of dysphagia and swallowing disorders have been blended with the current technology, and thus, serious advances have been made in determination of etiology of eating disorders. The most common of these are hiatal hernias, and there have been significant improvements in both understanding the pathophysiology of the disease and its treatment. In this study, we aimed to evaluate the results of 51 cases who underwent laparoscopic repair due to hiatal hernia in light of the literature.
METHODS: Between September 2011 and October 2014, laparoscopic Nissen and Toupet fundoplication operations performed by a single general surgeon for gastroesophageal reflux and hiatal hernia in SBU Ümraniye Training and Research Hospital, Department of General Surgery, were included retrospectively in this study. Demographic characteristics, complaints, comorbidities, type of hiatal hernia, previous operation, and early and late post-operative complication parameters of each case were evaluated. The results were evaluated in percentage analyses with SPSS v21 for Windows and presented with tables and graphs.
RESULTS: Fifty-one patients who underwent Nissen and Toupet fundoplication operations were included in the study. The mean age of all patients was 50.61±1.62 years. The mean ages of 23 male and 28 female patients were 48.30±2.69 years and 52.5±1.93 years, respectively. All but one patient underwent Nissen fundoplication. The time from diagnosis to surgery was 440.50±128.30 days. Post-operative hospital stay was 2.24±0.28 days. Four patients developed intraoperative (pleural defect in two patients, one liver injury, and one subcutaneous emphysema), and one patient developed early post-operative complications (postoperative atelectasis). In the 6th month control endoscopy, one patient had recurrence and the other patients had no pathology.
DISCUSSION AND CONCLUSION: Hiatal hernia is a common benign pathology that decreases quality of life. We believe that laparoscopic surgical repair is an effective method that can be safely applied after enough experience.

7. Etiology, Diagnosis, and Treatment in Childhood Atelectasis
Emine Atağ, Selen Ceren Çakmak, Sevinç Kalın, Büşra Kaya, Burcu Karakayalı, Seher Erdoğan, Almala Pınar Ergenekon, Ela Erdem Eralp, Sedat Öktem, Betül Sözeri
doi: 10.14744/hnhj.2020.97059  Pages 139 - 144
INTRODUCTION: Atelectasis is the loss of lung volume secondary to collapse. Narrow and collapsible airways and underlying chronic diseases facilitate the development of atelectasis in children. Since atelectasis is an important cause of morbidity and mortality in children, early diagnosis and treatment are of great importance.
METHODS: Thirty-six patients who were followed up in the pediatric service and pediatric intensive care unit of our clinic between December 1, 2018, and June 1, 2019, and were diagnosed radiologically with atelectasis were evaluated retrospectively.
RESULTS: The median age was 1.85 years (1.0–7.37). The most common cause for hospitalization was pneumonia (n=30, 83%). Except for two patients, all patients had an underlying disease that increased the risk of atelectasis. Neurological diseases were the most common diseases among the underlying diseases (n=12, 36%). For the treatment, 4 (11.1%) patients received chest physiotherapy, 19 (52.7%) patients received nebulized medications, and chest physiotherapy, and 13 (36.1%) patients received positive end-expiratory pressure support in addition to these treatments. The frequency of atelectasis in more than one localization was higher in children with the neurological disease than in other patients (n=7, [54%] vs. n=3, [13%]; p=0.018). In patients with atelectasis in more than one localization, the duration of hospitalization was longer (median 12.5 days [9.5–16.75] vs. 19 days [13–22.75]; p=0.034).
DISCUSSION AND CONCLUSION: Atelectasis is common in hospitalized children with an underlying disease. In the presence of pathological respiratory symptoms and signs, atelectasis should be kept in mind, and treatment should be started early.

8. The Relation Between Neutrophil-Lymphocyte Ratio and Etiologic Subtypes in Acute Ischaemic Stroke
Füsun Domaç, Mustafa Ülker, Rahşan Karacı, Mehmet Demir
doi: 10.14744/hnhj.2019.33255  Pages 145 - 148
INTRODUCTION: The role of leukocytes in tissue damage in acute ischaemic stroke is well-known. There are some studies examining the relationship between etiologic subtypes of acute ischaemic stroke and neutrophil/lymphocyte ratio (NLR). In this study, we planned to investigate the relationship between NLR and etiologic subtypes of acute ischaemic stroke.
METHODS: In this study, acute ischaemic stroke patients who were admitted to our hospital in the first 24 hours were included. Etiologic classification of patients was done by TOAST classification system. Patients who had history of acute coronary syndrome and pulmonary emboli were excluded.
RESULTS: We included 467 acute ischemic stroke patients and 162 control patients. Of the patients, 239 were females (51%) and 228 were males (49%). Of the control group, 77 (47%) were females and 85 (53%) were males. Mean ages in patient and control groups were 69.41±14.4 and 67.35±19.41, respectively. NLR’s in acute stroke and control groups were 3.38±3.43 and 2.12±1.11, respectively, and this difference was found to be statistically significant (p=0.001). NLR’S in atherothrombotic and cardioembolic groups were 3.26±2.35 and 4.46±5.6, respectively, and this was found to be statistically significant (p=0.03).
DISCUSSION AND CONCLUSION: High NLR was found to be related with cardioembolic etiology in acute ischaemic stroke. We think that more detailed investigation for cardioembolic sources may be necessary in patients with high NLR at first admission.


9. Evaluation of Clinical and Laboratory Findings of Patients Hospitalized for Urinary Tract Infection
Damla Mutlu, Nihan Uygur Külcü, Rabia Gönül Sezer, Abdülkadir Bozaykut
doi: 10.14744/hnhj.2019.61580  Pages 149 - 154
INTRODUCTION: Urinary tract infections (UTIs) are common and important because of their long-term consequences in childhood. The treatment of UTI consists mainly of antimicrobial agents to eliminate the symptoms, to prevent urosepsis, and to reduce the likelihood of renal damage. Here, we aimed to evaluate the clinical, laboratory findings of children hospitalized for UTI, in a 3-year period.
METHODS: Hospital records of the patients were investigated retrospectively. Data about demographic features, past and family history, clinical and laboratory findings, urine sampling methods, microorganisms isolated from urine culture, treatment duration, and recurrent hospitalization data were collected. Urinary system imaging (USG), dimercaptosuccinic acid scintigraphy, and voiding cystourethrography findings were obtained.
RESULTS: We enrolled 201 children aged between 1 month and 18 years (median age: 10 months) to our study. About 45.8% of children had urinary tract anomalies. The presence of recurrent UTI, congenital anomaly, and vesicoureteral reflux was 26.4%, 8.5%, and 8.5%, respectively. The most common symptoms were fever (54.2%), vomiting (22.9%), and dysuria (12.4%). Upper urinary tract involvement rate was 45.3%. Fever was observed in children with upper UTI significantly (p=0.0001) more than in children with lower UTI, while jaundice (p=0.004) and restlessness (p=0.039) were observed more in lower UTI than in upper UTI. Escherichia coli was the most isolated agent from urine cultures (74.6%). About 26.9% of cases (n=54) had pathologic urinary sonography (USG) findings. About 53.7% and 55.2% of cases had 99m Tc-DMSA scintigraphy and VCUG, respectively. Thirty-one cases with DMSA and 32 cases with VCUG had pathologic findings. Mean duration of treatment was 8.48±1.94 days.
DISCUSSION AND CONCLUSION: Urinary tract infections should be in differential diagnosis of infants with fever and vomiting. Appropriate antimicrobial and supportive treatment, urinary tract imaging studies, in relevant cases, multidisciplinary treatment, and follow-up are the main steps of UTI management. Treatment should be aimed according to resistant microorganisms in cases with urinary tract anomalies. Before initialization of treatment, urine culture should be done. Cases with renal scarring should be followed up for long-term complications.

10. Can Numerical Pain Rating Scale and Pain Catastrophic Scale Predict Lumbar Radiculopathy?
Osman Ersegun Batçık, Bülent Özdemir
doi: 10.14744/hnhj.2021.99266  Pages 155 - 159
INTRODUCTION: We wanted to investigate the relationship between the severity of pain and pain catastrophizing and Lasegue sign in patients with mechanical low back pain.
METHODS: Three hundred and forty-five people with low back pain were divided into two groups as positive and negative according to the Lasegue sign. Numerical rating scale for pain (NRS-P) and pain catastrophizing scale (PCS) were administered to the participants and the predictive power of these tests for the Lasegue sign was investigated.
RESULTS: The scores of both scales were found to be statistically significantly higher in the Lasegue positive group compared to the negative group. In the simple logistic regression analysis, it was determined that NRS-P and PCS could significantly predict Lasegue test positivity.
DISCUSSION AND CONCLUSION: It has been determined that NRS-P and PCS are tools that can be used for the presence of lumbar radiculopathy. The results of our study revealed that psychological factors such as catastrophizing are also important in the perception of pain, and it would be beneficial for clinicians to consider this situation while managing the treatment process.

11. Comparison of Femtosecond-Assisted Laser in Situ Keratomileusis and Wavefront-Guided Femtosecond-Assisted Laser in Situ Keratomileusis Procedures in Terms of High-Order Aberrations
Servet Çetinkaya
doi: 10.14744/hnhj.2019.38981  Pages 160 - 165
INTRODUCTION: To compare the results of femtosecond-assisted laser in situ keratomileusis (FS-LASIK) and wavefront-guided FS-LASIK (WFG FS-LASIK) procedures in terms of high-order aberrations (HOAs).
METHODS: One hundred and twenty-eight eyes of 64 patients with myopia and/or myopic astigmatism who had undergone FS-LASIK procedure comprised Group I. Their mean age was 27.87±5.49 (19–41) years. Thirty-two of them were male (50%) and 32 (50%) were female. One hundred and twenty-eight eyes of 64 patients with myopia and/or myopic astigmatism who had undergone WFG FS-LASIK procedure comprised Group II. Their mean age was 28.56±6.01 (19–42) years. Thirty-two of them were male (50%) and 32 (50%) were female. Two groups are compared with each other in terms of HOAs.
RESULTS: In respect to age and sex, there was no significant difference between FS-LASIK and WFG FS-LASIK groups (p>0.050). Regarding pre-operative and post-operative spherical, cylindrical, and spherical equivalent values, uncorrected distance visual acuity, and corrected distance visual acuity, there was no significant difference between two groups (p>0.050). FS-LASIK induced more spherical aberration, coma, and trefoil than WFG FS-LASIK (p=0.000).
DISCUSSION AND CONCLUSION: In conclusion, both FS-LASIK and WFG FS-LASIK are effective and safe procedures in the treatment of myopia and myopic astigmatism. FS-LASIK induces more spherical aberration, coma, and trefoil than WFG FS-LASIK procedure, meaning it causes more HOAs.


12. New Indicator of Inflammation in Migraine: Red Blood Cell Distribution
Zeynep Bastuğ Gül, Rabia Gökcen Gözübatık Çelik, Batuhan Selçuk, Sena Aksoy, Mehmet Gül, Aysun Soysal
doi: 10.14744/hnhj.2021.46872  Pages 166 - 171
INTRODUCTION: The role of inflammation in the pathophysiology of migraine is controversial. We aimed to investigate new inflammatory markers such as red blood cell distribution width (RDW) and plateletcrit in patients with migraine.
METHODS: In this study, 100 patients suffering from migraine and 67 healthy controls with similar demographic characteristics were included in the study. Complete blood count (CBC) including number of neutrophils, lymphocytes and platelets, RDW, plateletcrit, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fasting blood glucose, serum creatinine, and neutrophil-to-lymphocyte ratio (NLR) was compared between these two groups. SPSS was used for statistical analysis.
RESULTS: There was positive correlation between RDW and migraine group, CRP, plateletcrit, platelet, and neutrophil counts. The results of ESR, platelet count and RDW in migraine group were higher than control group significantly (p=0.044, p=0.024, and p=0.002, respectively). CRP, NLR, and plateletcrit were higher in migraine group without significance. In multivariate analysis, RDW was found as a significant independent predictor of migraine after adjusting for other risk factors (p=0.048). In a receiver operating characteristic curve analysis, an RDW value of 13.25% was identified as an effective cutoff point for migraine (area under curve = 0.620, 95% confidence interval: 0.53–0.71, p=0.009). An RDW value of more than 13.25% yielded a sensitivity of 58% and a specificity of 54%.
DISCUSSION AND CONCLUSION: In our study, we found that RDW was higher in patients with migraine than control group, independent of other variables. RDW can be used as an inflammatory marker for migraine with a simple and inexpensive CB examination.

13. The Effect of Fibromyalgia on Bone Mineral Density in Patients with Hypothyroidism
Yaşar Keskin, Teoman Aydın, Berna Ürkmez, Özgür Taşpınar, Ahmet Adil Çamlı, Huriye Şenay Kızıltan, Ali Hikmet Eriş, Ahmet Serdar Mutluer
doi: 10.14744/hnhj.2019.78941  Pages 172 - 176
INTRODUCTION: The aim of this study was to investigate whether the presence of fibromyalgia affects the bone mineral density (BMD) in hypothyroid patients.
METHODS: Our study consisted of three groups, including 30 patients with hypothyroidism and FMS, 30 patients with hypothyroidism, and 27 healthy volunteers. Lumbar vertebrae and left proximal femur BMD measurements of groups were performed by dual-energy X-ray absorptiometry. Groups were compared in terms of BMD.
RESULTS: Lumbar spinal total T score and lumbar spinal total BMD were significantly different between healthy volunteers and the other two groups. However, no significant difference was found between the groups in terms of age, gender, body mass index, smoking and alcohol use habits, erythrocyte sedimentation rate, C-reactive protein, thyroid-stimulating hormone, fT3, fT4, and 25-OH Vitamin D.
DISCUSSION AND CONCLUSION: BMD was lower in patients with hypothyroidism and in patients with both fibromyalgia and hypothyroidism compared with healthy individuals. However, there was no difference in BMD between patients with both fibromyalgia and hypothyroidism and only with hypothyroidism.

14. Mean Platelet Volume as an Early Predictor for The Complication of Coronavirus Disease 19
Meltem Sertbaş, Selma Dağcı, Volkan Kızılay, Zeynep Yazıcı, Ebru Elçi, Özlem Güdük, Serkan Elarslan, Bengü Şaylan, Akın Dayan, Yaşar Sertbaş, Kamil Özdil
doi: 10.14744/hnhj.2020.90582  Pages 177 - 182
INTRODUCTION: Although several studies have been conducted on the association of mean platelet volume (MPV) with the diagnosis, morbidity, and mortality of coronavirus disease 19 (COVID-19) patients, the results were contradictory. We aimed to investigate the effects of MPV on hospitalization and mortality with a significant number of patients.
METHODS: This multicenter study was carried out retrospectively on 9.487 patients. The demographic information and laboratory parameters of the patients were obtained from their medical records in the hospital. Analyses were performed using Statistical Package for the Social Sciences (SPSS) version 22.0 for Windows.
RESULTS: In total, there were 806 intensive care unit (ICU) patients, in addition to 8.681 non-ICU patients. The mean age of patients in ICU was significantly higher than non-ICU (71.25±13.42 vs. 56.17±16.59; p<0.001). MPV values at admission and max MPV values during the period of hospitalization were significantly higher in patients followed in the ICU (p<0.05). MPVfirst, MPVlast, ΔMPVlast-first, and ΔMPV% values were significantly higher in non-survivor group than the survived patients. As a result of receiver-operating characteristic analysis, the risk of mortality was determined to be 5.15 fold greater in people with MPVlast ≥10.05 fl. (ODDS ratio: 5.15 95% CI: 4.374–6.067). The patient has a 4.62 fold risk of death after a 2.18% increase of arrival MPV value (ODDS ratio: 4.62, 95% CI: 3.455-6.203).
DISCUSSION AND CONCLUSION: We thought that MPV and MPV changes during hospitalization may be a powerful predictor of mortality in patients with COVID-19.

15. Comparison of Ibuprofen Protocols in the Pharmacological Treatment of Patent Ductus Arteriosus
Yeşim Coşkun, İpek Akman, Gülendam Koçak
doi: 10.14744/hnhj.2019.69077  Pages 183 - 188
INTRODUCTION: Ibuprofen (IBU) is an effective agent for the pharmacological treatment of patent ductus arteriosus (PDA) in premature infants. In this study, we compared the efficacy and complications of intravenous bolus therapy (IVBT) and continuous intravenous infusion therapy (CIVIT) for the treatment of PDA.
METHODS: The study was conducted with 64 preterm infants in neonatal intensive care unit with gestational age <34 weeks between 2015 and 2018. Demographic characteristics, clinical findings, complications, and response to treatment were evaluated.
RESULTS: IBU treatment with a standard dose (10/5/5 mg/kg) was given as IVBT in 48.4% (n=31) of the patients and as CIVIT 51.6% (n=33) of the patients. The efficacy and the side effects of the treatment modalities were compared. In CIVIT group, feeding intolerance was found in 6 patients (18.2%) and none of them had Stage 3 necrotizing enterocolitis (NEC). In the IVBT group, 15 patients (48.4%) had feeding intolerance and 3 patients (9.7%) had Stage 3 NEC. Surgical ligation was needed in 3 (9.7%) patients who received IVBT. There was no need for surgical ligation in patients who received CIVIT. No significant difference was found between two groups in terms of mortality, hospital stay, periventricular hemorrhage, and side effects such as oliguria, renal insufficiency, hyponatremia, and bleeding diathesis.
DISCUSSION AND CONCLUSION: When IBU is used as CIVIT for the pharmacological treatment of PDA, we found that the risk of developing feeding intolerance and NEC is less than IVBT. These results should be studied with larger sample sizes.

16. Computed Tomography Prediction of Resectability of Pancreatic Adenocarcinoma Using National Comprehensive Cancer Network Criteria
Levent Soydan, Mehmet Torun, Ceren Karabiber Deveci, Turgay Oner, Kamil Canpolat, Umut Kına, Ismail Ege Subaşı
doi: 10.14744/hnhj.2021.05668  Pages 189 - 196
INTRODUCTION: We evaluated the diagnostic accuracy of computed tomography (CT) in determining resectability of pancreatic adenocarcinoma using National Comprehensive Cancer Network (NCCN) Criteria.
METHODS: Two radiologists retrospectively reviewed abdominal CT images from 36 patients with non-metastatic pancreatic adenocarcinoma who were operated on between 2018 and 20120. Based on CT findings six patients were reported as resectable, seven patients as borderline resectable, and 23 patients as unresectable using NCCN criteria for resectability. Positive predictive values for negative resection margin (R0) were assessed for CT using post-operative histopathological reports as reference standards.
RESULTS: In 36 patients who preceded to surgery R0 resection rates were 83% (5 of 6), 71% (5 of 7), and 60% (14 of 23) for resectable, borderline resectable, and unresectable disease, respectively (p<0.001).
DISCUSSION AND CONCLUSION: CT can be used to identify patients with pancreatic cancer who can benefit from surgery with the possibility of R0 resection. Our study results showed that using NCCN guidelines the diagnostic accuracy of CT to predict R0 resection can be improved.

17. Comparison of Rifaximin and Trimebutin Maleate Treatment for Irritable Bowel Syndrome with Constipation and Diarrhea
Bilge Örmeci Baş
doi: 10.14744/hnhj.2019.20438  Pages 197 - 203
INTRODUCTION: Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with changes in bowel habits, abdominal pain, and gas without any organic pathology. IBS is divided into three types as constipation – IBS (IBS-C), diarrhea – IBS (IBS-D), and mixed. Rifaximin is an antibiotic that improves IBS symptoms by improving the flora in the intestine. The aim of the study was to determine whether the treatment of rifaximin is superior to treatment.
METHODS: This study performed retrospectively and patients were divided into two groups as IBS-C and IBS-D. Each group was divided into two groups as rifaximin and Trimebutin Maleate treatment. Rifaximin at a dose of 200 mg, 3×2 daily for 15 days. Trimebutin Maleate group includes lifestyle modification and Trimebutin Maleate 200 mg 3×1. At the end of the treatment and after 20 days, the patients were re-evaluated.
RESULTS: A total of 179 subjects had examined. In terms of IBS symptoms; bloating, abdominal pain, and stool consistency, both treatments are effective as long as patients continue treatment; however, 20 days after the end of the treatment, rifaximin treatment was found to be more effective than trimebutin maleate treatment.
DISCUSSION AND CONCLUSION: The use of rifaximin provides significant long-term improvement in both diarrhea and constipation IBS patients compared to Trimebutin Maleate treatment.

18. Multivisceral Resections for Locally Advanced Colorectal Cancer: Morbidity and Mortality
Ali Sürmelioğlu, Metin Tilki, Gülten Çiçek Okuyan
doi: 10.14744/hnhj.2021.66588  Pages 204 - 208
INTRODUCTION: Multivisceral organ resection is recommended in patients with locally advanced colorectal cancer. The aim of this study was to determine the influence of additional organ resection on morbidity and mortality on short term.
METHODS: Patients who underwent curative resection for colorectal cancer were included in the study. They were divided into two groups as multivisceral resection groups (MRGs) and standard resection groups (SRGs). The patients were compared in terms of demographics, tumor localization, operation time, blood loss, length of hospital stay, and post-operative morbidity and mortality. In statistical analysis, Mann–Whitney U and chi-square tests were used.
RESULTS: Thirty-two (10.1%) of 316 patients were in the MRG and 284 (89.9%) in the SRG. Male/female ratio, presence of comorbid diseases, and tumor localization were similar in the groups. Hospital stay (8.4±4.2 vs. 8.2±6.2 days) was also similar. Operation time (221±62.3 vs. 181±70.1 min) was longer and blood loss (180 [50–410] cc vs. 150 [40–390] cc) was significantly higher in the MRG (p<0.001 and p<0.001, respectively). There was no statistically significant difference with regard to morbidity (21.8% vs. 20.8%) and mortality (3.1% vs. 3.5%). In the MRG, histopathologically confirmed tumoral invasion (T4) was detected in 17 (53.1%) patients for whom multiorgan resection was performed.
DISCUSSION AND CONCLUSION: Multiorgan resections can be performed with acceptable morbidity and mortality in specialized centers.

19. The Effect of Family Medicine Implementation on Primary Health Care Services: Northeast Anatolia Region Evaluation
Hasan Bağcı, Memet Taşkın Egici, Dilek Öztaş, Mehmet Ziya Gençer, Gözde Nizamoğlu Mercan
doi: 10.14744/hnhj.2020.98215  Pages 209 - 216
INTRODUCTION: Eastern region of Turkey faces challenges in the provision of health-care services due to insufficient human resources and geographical difficulties. In our study, periodic changes and effects of family medicine (FM) practice on the parameters of first step health-care of Northeast Anatolia Region (NAR) are examined.
METHODS: In the descriptive and cross-sectional retrospective study, basic health data of NAR obtained from open sources between 2008 and 2018 were compared within the scope of Nomenclature of Territorial Units for Statistics. Microsoft Excel 2016 was used for calculations.
RESULTS: In the region, access to Primary Health-Care (PHC) got easier, the number of doctors and nurses-midwives rose by 24.6% and the number of applications for PHC increased by 42% in 2018 compared to 2008. In Turkey, while the average per capita population of 3405 family physicians, the NAR’s population has been in the family physician per 3252 people as top average. The monitoring numbers recorded even higher increases with a 45% increase in pregnancy monitoring, 166% rises in post-puerperal monitoring, 57% growth in average monitoring per baby, and an average increase of 29% in monitoring per child were recorded. Whereas maternal death rate was 22.9 in the region for every one hundred thousand births versus a countrywide average of 19.4 in 2008, these rates were recorded as 24.9 and 13.6, respectively, in 2018. It could be argued that maternal rates fell by one third compared to 2006 and the approximately same rate was maintained between 2008 and 2018 but it was higher than the average of Turkey. Compared to 2008, the infant mortality rate in the region was 17.8 per thousand live births, but decreased by 40% and fell to 10.6. While the rate of Quinary Composit Vaccination (DaBT+IPA+Hib) was 74% in 2002, it was observed as 96% in 2008 and exceeded the Turkey average with 100% in 2010 when FM practice became widespread, this rate fell back down to 93% in 2018. The pace of Measles, Rubella, and Parotitis vaccination pace slowed by 6% as well. Fall in vaccination rates contrary to the general improvement in parameters could be attributed to vaccination reluctances, administrative changes, geographical difficulties, the high turnover rate among the health professionals, and difficulty to detect the target population before FM Practice.
DISCUSSION AND CONCLUSION: With improvements in health-care followed by FM practice, generally positive results were recorded in terms of service integration, access to protective health-care thanks to the balanced distribution of health personnel, and raising the basic health level indicators. More attention should be paid to maternal mortality and immunization in the region. To the sustainability of quality of care in PHC, population per FM should be reduced, specialization should be prioritized, and FM should be supported with integrated health-care models that unite various disciplines at the first step enabling early diagnosis and management of chronic diseases and disease management. If the FM system which is implemented for almost 15 years in our country is continuously updated according to needs, promising signs for the health of our nation could be expected for the future.

20. Cytological Differential Diagnosis Criteria of Liver Masses
Davut Şahin
doi: 10.14744/hnhj.2019.22599  Pages 217 - 222
INTRODUCTION: The objective of the study was to determine the critical diagnostic cytological features of the liver masses.
METHODS: This retrospective study was conducted with 137 fine needle aspiration biopsies diagnosed in a 5-year period in Haydarpaşa Numune Hospital. All the glass slides of the cases were re-evaluated and 11 cytomorphologic features were investigated in each case. The results were evaluated by Stepwise Logistic Regression Analysis method.
RESULTS: Monotonous atypia, atypical hepatocytic naked nuclei, increased nucleus/cytoplasm (N/C) ratio, and hepatocytic morphology were critical for differential diagnosis of hepatocellular carcinoma (HCC) and metastasis. Increase N/C ratio and the absence of bile duct epithelial cells were critically important for differential diagnosis of HCC from benign liver mass.
DISCUSSION AND CONCLUSION: Cytological diagnosis of liver mass is not difficult in cases where cytomorphological features are sufficient. The efficacy of cytology in the differentiation of benign liver masses from HCC is limited. This can be achieved by performing immunohistochemistry to the cell block. Cytopathologic diagnosis should be confirmed with radiological and biochemical results.

21. Clinical Characteristics of Suicide Attempts During Pregnancy
Nihat Müjdat Hökenek, Hidayet Ece Arat Çelik, Davut Tekyol, İbrahim Aydın, Gökhan Eyüpoğlu
doi: 10.14744/hnhj.2020.52296  Pages 223 - 226
INTRODUCTION: Suicide is one of the most important causes of female deaths during pregnancy and postpartum period. The aim of this study is to examine the sociodemographic and clinical characteristics of patients who applied to the emergency department for suicide attempts during pregnancy.
METHODS: This is a retrospective study. Pregnant patients (n=46), between the ages of 18 and 50, admitted to the emergency department for suicide attempt between January 2009 and December 2019 were included in the study.
RESULTS: The mean age of the pregnant was 27.74 (SD=5.99). The most common suicide attempts were in the 15th week of gestation. Pregnant mostly attempted suicide in the 1st trimester (52.2%). The most commonly used method for suicide was overdose medication (80.4%). This was followed by exposure to toxic substances (10.9%), jumping from high (4.3%), and self-injury (4.3%). About 37% of the pregnant had a psychiatric history and used psychiatric drugs. About 15.2% of the pregnant had a past suicide attempt.
DISCUSSION AND CONCLUSION: Suicide is a preventable psychiatric situation. It can be prevented in pregnant by asking for their current mental health and psychiatric history during early pregnancy assessments.

22. Prediction of In-Hospital Mortality in ST-Segment Elevation Myocardial Infarction: What is the Role of Thrombolysis in Myocardial Infarction Risk Index?
Burcu Genç Yavuz, Mustafa Ahmet Afacan, İsmail Tayfur, Can Yucel Karabay, Mehmet Koşargelir, Özlem Tataroğlu, Onur Incealtın, Davut Tekyol
doi: 10.14744/hnhj.2020.10693  Pages 227 - 233
INTRODUCTION: Thrombolysis in myocardial infarction (TIMI) risk index has been developed to predict the prognosis in patients with coronary artery disease. In this study, we evaluated the prognostic value of TIMI risk index in patients with ST-segment elevation myocardial infarction (STEMI) when TIMI risk index was calculated in the emergency department (ED) and patients were referred to an interventional center.
METHODS: In this retrospective analysis, we evaluated the in-hospital mortality prognostic impact of TIMI risk index on 944 patients with STEMI treated with primary percutaneous coronary intervention. Patients were divided into two groups according to the presence of in-hospital mortality and the baseline features were compared between these groups. Multivariate analysis was implemented to detect independent predictors of in-hospital mortality.
RESULTS: TIMI risk index was an independent predictor (OR: 5.75; 95% confidence interval: 2.09–15.8; p=0.0007) of in-hospital mortality besides Killip stage, chronic kidney disease, and total ischemic time according to the results of the multivariate regression analysis. ROC analysis showed that the best cutoff value of the TIMI risk index to predict in-hospital mortality was 29.3 with 79.1% sensitivity and 80.7% specificity.
DISCUSSION AND CONCLUSION: Our study indicated that TIMI risk index calculated in the ED is an independent prognostic factor for in-hospital mortality in patients with STEMI.

REVIEW
23. The Role of High-Resolution Computed Tomography in the Evaluation of Pneumoconiosis
Levent Soydan
doi: 10.14744/hnhj.2020.23590  Pages 234 - 240
Inhalation of dust, noxious agents, or fume in certain occupational environments may cause pulmonary damage in exposed workers. Recognition of these pneumoconiosis is important both for treatment and prevention of the disease condition. Although may pneumoconiosis may be detected by chest X-ray, the use of high-resolution computed tomography (HRCT) combined with exposure history and clinical features allows to reach to a specific diagnosis or at least to narrow the differential diagnosis thanks to its ability to demonstrate lung parenchymal architecture in a superior way. In this article, we review the common HRCT appearances of a spectrum of occupational lung diseases.

CASE REPORT
24. A Case of Tuberculous Meningitis Presenting with Non-Specific Findings
Erkan Yetmiş, Zehra Esra Önal, Çağatay Nuhoğlu
doi: 10.14744/hnhj.2019.79553  Pages 241 - 244
Tuberculosis (TB) is still a major public health problem in developing and developed countries. Extrapulmonary TB (EPTB) may mimic malignancies and many other diseases, and it should be kept in mind in the differential diagnosis. Tuberculous meningitis (TM) has high mortality and morbidity rates among EPTB forms. Mortality and morbidity rates are reduced by early diagnosis and treatment in TM.

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